此条目介绍的是NADP为受体的酶。关于同名但以NAD为受体的酶,请见“羟甲基戊二酸单酰辅酶A还原酶”。
羟甲基戊二酸单酰辅酶A还原酶 (NADPH)
羟甲基戊二酸单酰辅酶A还原酶晶体结构(PDB 1dq8)
命名
系统命名(R)-mevalonate:NADP oxidoreductase (CoA-acylating)
缩写
别名hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); S-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2)
识别码
EC编号1.1.1.34
CAS号9028-35-7
数据库
IntEnzIntEnz浏览
BRENDA英语BRENDABRENDA入口
ExPASy英语ExPASyNiceZyme浏览
KEGGKEGG入口
MetaCyc英语MetaCyc代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles概述
PDBRCSB PDB PDBj PDBe PDBsum
基因本体AmiGO / EGO
搜索
PMC相关文献
PubMed相关文献

羟甲基戊二酸单酰辅酶A还原酶 (NADPH)(英语:hydroxymethylglutaryl-CoA reductase (NADPH),EC 1.1.1.34)是一种以NAD或NADP为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应:

(R)-甲羟戊酸 + CoA + 2 NADP {\displaystyle \rightleftharpoons } (S)-3-羟基-3-甲基戊二酰辅酶A + 2 NADPH + 2 H

羟甲基戊二酸单酰辅酶A还原酶 (NADPH)主要参与诸如胆固醇等类固醇的合成。用于降低胆固醇的他汀类药物通过抑制这种酶来发挥作用。

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